Here I started with fresh OSX 10.6.4 with has preinstalled 2.6.1 (open console and type python).
- Install newest python (2.6.5 tested) 
- Download and install latest stable Numpy.
- Download and install latest Scipy
- Install PIL (or skip, probably you won't need it)
- Install MacTex
- Install PyX
sudo python setup.py install
- Install PyNomo
Run tests on examples directory found in zip-distribution
If everything ok, you should see pdf documents generated.
Note that for example running scripts in easy-eclipse-for-python do not work due to unknown difference between console running and easy-eclipse-for-python running.
Tested to work 6th August 2010 on by Leif.